Significant Psilocybin studies

Significant Psilocybin studies

2006 - mystical type experiences

Psilocybin can cause mystical experiences very similar to those reported occurring spontaneously by mystics throughout history. Most participants described them as being among the most personally meaningful and spiritually significant of their lives.

Roland Griffiths @ Johns Hopkins Institute

2011 - positive effects in healthy people

Psilocybin administered to healthy persons was recognized to be pleasurable, enriching and non-threatening. Negative effects can be mitigated by interpersonal support.

Studerus, paper of pooled data from 8 studies & a total of 110 healthy volunteers

2015 - treating addiction to alcohol

Psilocybin shows great promise, treating addiction. For alcoholism, it seems results (enduring abstinence) are tied to the intensity of experience.

Bogenshutz, Strassman

2016 - challenging experiences

Although counting among the safest of substances, mushrooms can produce challenging experiences. However, 84% of people in hindsight endorse these expereinces to have been greatly beneficial to their lives.

Carbonaro, Johns Hopkins University School of Medicine

2017 - smoking addiction

Psilocybin shows great promise in addiction treatment.
12 months after the experience, 67% of participants were completely smoke-free, while 86.7% rated the experience as among the most meaningful of their lives.

Johnson, Garcia-Romeu, Roland Griffiths @ Johns Hopkins Institute

2017 - therapeutic mechanism: creative thinking, empathy, well-being

Consumption of magic mushrooms in a retreat setting may help bring about a shift of consciousness over time, from separation to connection.
Creative thinking, empathy and life satisfaction were all perceived as improved in the following week.

Natasha Mason, Faculty of Psychology and Neuroscience @ Maastricht University

2018 - nature connection

During a study testing the efficacy against treatment-resistant depression participants noted that they were feeling more connected to nature up to a  year later.  They also noted feeling less prone to authoritarian views.

Lyons, Carhart-Harris @ Journal of Psychopharmacology 

2018 - treatment-resistant depression

Efficacy of psilocybin against severe, uni-polar, treatment-resistant depression, in combination with psychological support: 31% of participants reported anti-depressant effects 6 months after the experience.
No patients sought conventional antidepressant treatment within 5 weeks of psilocybin.

Carhart-Harris, Nutt @ Journal of Psychopharmacology 


2018 - combination with spiritual practices

Psychedelic integration especially paired with spiritual practices like meditation or journaling causes enduring shifts in prosocial values and behaviour, while promoting healthy psychological functioning.

Johns Hopkins University School of Medicine

2019 Creative thinking, empathy and wellbeing

Taking psilocybin mushrooms in a retreat settingcan improve the lives of healthy people, even at lower doses.


2020 Psilocybin and existencial anxiety

In 3 seperate studies, existential anxiety in terminally ill cancer patients seems to be mitigated by a single psilocybin experience, with benefits highly enduring. A follow-up study of surviving NYU participants conducted four and a half years later reported sustained antidepressant and anti-anxiety effects, with participants considering their experiences as among the most deeply profound of their lives.

UCLA, Johns Hopkins and NYU


Corresponding study links

2011 - positive effects in healthy people

2015 - psilocybin against alcohol addiction

2016 - challenging experiences

2017 - psilocybin against nicotine addiction

2017: therapeutic mechanisms

2018 - nature connection

2018 - treatment-resistant depression

2018 - spiritual practices

2019 - creative thinking, empathy and wellbeing

2020 - existencial anxiety

Back to blog