2006 - mystical type experiences
Psilocybin can cause mystical experiences very similar to those reported occurring spontaneously by mystics throughout history. Most participants described them as being among the most personally meaningful and spiritually significant of their lives.
Roland Griffiths @ Johns Hopkins Institute
2011 - positive effects in healthy people
Psilocybin administered to healthy persons was recognized to be pleasurable, enriching and non-threatening. Negative effects can be mitigated by interpersonal support.
Studerus, paper of pooled data from 8 studies & a total of 110 healthy volunteers
2015 - treating addiction to alcohol
Psilocybin shows great promise, treating addiction. For alcoholism, it seems results (enduring abstinence) are tied to the intensity of experience.
2016 - challenging experiences
Although counting among the safest of substances, mushrooms can produce challenging experiences. However, 84% of people in hindsight endorse these expereinces to have been greatly beneficial to their lives.
Carbonaro, Johns Hopkins University School of Medicine
2017 - smoking addiction
Psilocybin shows great promise in addiction treatment.
12 months after the experience, 67% of participants were completely smoke-free, while 86.7% rated the experience as among the most meaningful of their lives.
Johnson, Garcia-Romeu, Roland Griffiths @ Johns Hopkins Institute
2017 - therapeutic mechanism: creative thinking, empathy, well-being
Consumption of magic mushrooms in a retreat setting may help bring about a shift of consciousness over time, from separation to connection.
Creative thinking, empathy and life satisfaction were all perceived as improved in the following week.
Natasha Mason, Faculty of Psychology and Neuroscience @ Maastricht University
2018 - nature connection
During a study testing the efficacy against treatment-resistant depression participants noted that they were feeling more connected to nature up to a year later. They also noted feeling less prone to authoritarian views.
Lyons, Carhart-Harris @ Journal of Psychopharmacology
2018 - treatment-resistant depression
Efficacy of psilocybin against severe, uni-polar, treatment-resistant depression, in combination with psychological support: 31% of participants reported anti-depressant effects 6 months after the experience.
No patients sought conventional antidepressant treatment within 5 weeks of psilocybin.
Carhart-Harris, Nutt @ Journal of Psychopharmacology
2018 - combination with spiritual practices
Psychedelic integration especially paired with spiritual practices like meditation or journaling causes enduring shifts in prosocial values and behaviour, while promoting healthy psychological functioning.
Johns Hopkins University School of Medicine
2019 Creative thinking, empathy and wellbeing
Taking psilocybin mushrooms in a retreat settingcan improve the lives of healthy people, even at lower doses.
2020 Psilocybin and existencial anxiety
In 3 seperate studies, existential anxiety in terminally ill cancer patients seems to be mitigated by a single psilocybin experience, with benefits highly enduring. A follow-up study of surviving NYU participants conducted four and a half years later reported sustained antidepressant and anti-anxiety effects, with participants considering their experiences as among the most deeply profound of their lives.
UCLA, Johns Hopkins and NYU